Pubmed search “Cognitive Function” in the last 5 years, Adult: 19+ years, Aged: 65+ years.
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The Effect of Aerobic Exercise on Cognitive Function in People with Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials 2022
Shiyan Zhang 1 2 , Kai Zhen 1 2 , Qing Su 3 , Yiyan Chen 2 , Yuanyuan Lv 1 4 , Laikang Yu 1 2
Our analysis indicated that aerobic exercise, especially conducted 30 min per session, less than 150 min per week, and up to three times per week, contributed to improving cognitive function in AD patients
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs 2022
Daniel Gallardo-Gómez 1 , Jesús Del Pozo-Cruz 2 , Michael Noetel 3 , Francisco Álvarez-Barbosa 4 , Rosa María Alfonso-Rosa 5 , Borja Del Pozo Cruz 6
Resistance exercise superior at 724 mets/week
The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Systematic Review and Meta-analysis 2023
Tim Whitfield 1 , Thorsten Barnhofer # 2 , Rebecca Acabchuk # 3 , Avi Cohen 4 , Michael Lee 4 , Marco Schlosser 4 5 , Eider M Arenaza-Urquijo 6 , Adriana Böttcher 7 , Willoughby Britton 8 , Nina Coll-Padros 9 , Fabienne Collette 10 , Gaël Chételat 11 , Sophie Dautricourt 11 , Harriet Demnitz-King 4 , Travis Dumais 12 , Olga Klimecki 5 , Dix Meiberth 13 , Inès Moulinet 11 , Theresa Müller 13 , Elizabeth Parsons 4 , Lauren Sager 12 , Lena Sannemann 13 , Jodi Scharf 12 , Ann-Katrin Schild 13 , Edelweiss Touron 11 , Miranka Wirth 7 , Zuzana Walker 4 14 , Ethan Moitra 8 , Antoine Lutz 15 , Sara W Lazar 16 , David Vago 17 , Natalie L Marchant 4
The summary effect size for all studies favored MBPs over comparators and was small in magnitude (g = 0.15; [0.05, 0.24]). Across subgroup analyses of individual cognitive domains/subdomains, MBPs outperformed comparators for executive function (g = 0.15; [0.02, 0.27]) and working memory outcomes (g = 0.23; [0.11, 0.36]) only.
Nutrition and cognitive health: A life course approach 2023
Seema Puri 1 , Majida Shaheen 1 , Bhanvi Grover 1
Several micronutrients like B group vitamins and iron, as well as many polyphenols play a crucial role in cognitive health. Mediterranean, Nordic, DASH, and MIND diets are linked to a lower risk of cognitive decline and dementia. The relationship between the gut microbiome and brain function through the gut-brain axis has led to the emergence of data on the beneficial effects of dietary fibers and probiotics through the management of gut microbes. A "whole diet" approach as well as macro- and micro-nutrient intake levels that have protective effects against cardiovascular diseases are most likely to be effective against neurodegenerative disorders too.
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis 2023
Minggang Zhang 1 , Jiafeng Jia 1 , Yang Yang 1 , Lepu Zhang 1 , Xiaochun Wang 2
Exercise benefitted overall cognition and all subcognitive domains. Aerobic and resistance exercise showed the greatest benefits on global cognition and executive function respectively, whereas mind-body exercise benefitted memory. Among all populations, older adults showed the greatest benefits of exercise on global cognition, executive function, and memory compared with controls
Cognitive stimulation and cognitive results in older adults: A systematic review and meta-analysis 2023
Isabel Gómez-Soria a b, Isabel Iguacel a b c, Alejandra Aguilar-Latorre b, Patricia Peralta-Marrupe a, Eva Latorre c d, Juan Nicolás Cuenca Zaldívar e f, Estela Calatayud a b
• Cognitive stimulation (CS) improves general cognitive functioning in older adults cognitively healthy, or with mild cognitive impairment (MCI) or dementia.
• All types of CS seem to be beneficial to enhance cognitive functioning in older adults, specially, reminiscence therapy, reality orientation and multisensory stimulation.
• CS improves specific cognitive domains such as memory, orientation, language, praxis, and calculation in older adults cognitively healthy, or with MCI or dementia.
• CS increases general cognitive functioning, memory, orientation, and praxis in older adults ≤ 75 years.
The Effects of Age-Related Hearing Loss on the Brain and Cognitive Function.
Slade K, Plack CJ, Nuttall HE. 2020
Most modifiable risk factor
Sleep Duration and Executive Function in Adults
Aayushi Sen 1 2 , Xin You Tai 3 4
Poor sleep efficiency and sleep fragmentation are linked with poorer executive function and increased risk of dementia during follow-up. Sleep quality may therefore be more important than absolute duration.
Lu X, Liu C, Shao F. Phototherapy improves cognitive function in dementia: A systematic review and meta-analysis. Brain Behav. 2023 May;13(5):e2952. doi: 10.1002/brb3.2952. Epub 2023 Apr 5. PMID: 37017012; PMCID: PMC10176000.
phototherapy interventions significantly improved MMSE scores (n = 3, MD 2.68, 95% confidence interval [CI]: 1.38–3.98 near infrared
Yang Y, Wang K, Liu S, Liu H, Zhang T, Luo J. Exergames improve cognitive function in older adults and their possible mechanisms: A systematic review. J Glob Health. 2023 Dec 1;13:04177. doi: 10.7189/jogh.13.04177. PMID: 38038376; PMCID: PMC10691300.
Exergeme is an interactive product that combines body movements with technology and gaming, where individuals interact with virtual environments through their actions, requiring input from body movements and cognitive tasks (such as considering continuous feedback and quick decision-making) to control the output of game terminals during operation [8]. Nowadays, there are many types of body feeling games, with Nintendo Wii from Japan, Sony PlayStation from Japan, Xbox Kinect from the United States and Idong from China being the main types of body feeling games used in the field of sports rehabilitation
Suh SW, Lim E, Burm SY, Lee H, Bae JB, Han JW, Kim KW. The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis. BMC Med. 2024 Mar 12;22(1):109. doi: 10.1186/s12916-024-03296-0. PMID: 38468309; PMCID: PMC10929146.
The current meta-analysis on 24 studies (n 9660; follow-up 3 to 36 months) found that the beneficial effect on executive function demonstrates an upward trend within the initial 12 months of intervention. This effect is prominently observed with a daily intake surpassing 500 mg of n-3 PUFA and up to 420 mg of eicosapentaenoic acid (EPA). Furthermore, these trends exhibit heightened significance in regions where the levels of blood docosahexaenoic acid (DHA) + EPA are not very low.
Shantakumari N, Ahmed M. Whole body vibration therapy and cognitive functions: a systematic review. AIMS Neurosci. 2023 May 18;10(2):130-143. doi: 10.3934/Neuroscience.2023010. PMID: 37426779; PMCID: PMC10323263.
Results of the review suggest that whole-body vibration therapy enhances a wide spectrum of cognitive functions in adults although there isn't enough evidence available yet to be able to design a standardized protocol to achieve optimum cognitive enhancement.
Li J, Abdel-Aal EM. Dietary Lutein and Cognitive Function in Adults: A Meta-Analysis of Randomized Controlled Trials. Molecules. 2021 Sep 24;26(19):5794. doi: 10.3390/molecules26195794. PMID: 34641336; PMCID: PMC8510423.
Although dietary lutein did not significantly improve cognitive performance, the evidence across multiple studies suggests that lutein may nonetheless prevent cognitive decline, especially executive function.
Gutierrez L, Folch A, Rojas M, Cantero JL, Atienza M, Folch J, Camins A, Ruiz A, Papandreou C, Bulló M. Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials. Nutrients. 2021 Oct 22;13(11):3728. doi: 10.3390/nu13113728. PMID: 34835984; PMCID: PMC8621754.
There was reasonable evidence that dietary patterns, as well as food and dietary supplements improved cognitive domains or measures of brain integrity. The Mediterranean diet showed promising results, whereas the role of the DASH diet was not clear. Healthy food consumption improved cognitive function, although the quality of these studies was relatively low. The role of dietary supplements was mixed, with strong evidence of the benefits of polyphenols and combinations of nutrients, but with low evidence for PUFAs, vitamin D, specific protein, amino acids, and other types of supplements
Li S, Tang Y, Zhou Y, Ni Y. Effects of Transcranial Direct Current Stimulation on Cognitive Function in Older Adults with and without Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Gerontology. 2024;70(5):544-560. doi: 10.1159/000537848. Epub 2024 Mar 8. PMID: 38452749.
tDCS can significantly improve the immediate postintervention cognitive function of healthy older adults and MCI elderly individuals. Additional longitudinal extensive sample studies are required to clarify the specific effects of tDCS on different cognitive domains, and the optimal tDCS parameters need to be explored to guide clinical practice.
Prokopidis K, Giannos P, Triantafyllidis KK, Kechagias KS, Forbes SC, Candow DG. Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2023 Mar 10;81(4):416-427. doi: 10.1093/nutrit/nuac064. PMID: 35984306; PMCID: PMC9999677.
Creatine supplementation enhanced measures of memory performance in healthy individuals, especially in older adults (66-76 years).
Suh SW, Kim HS, Han JH, Bae JB, Oh DJ, Han JW, Kim KW. Efficacy of Vitamins on Cognitive Function of Non-Demented People: A Systematic Review and Meta-Analysis. Nutrients. 2020 Apr 22;12(4):1168. doi: 10.3390/nu12041168. PMID: 32331312; PMCID: PMC7231132.
Twenty-three studies on B vitamins (n = 22-1053; comprising folate, B6, and B12), nine on antioxidant vitamins (n = 185-20,469), and six on vitamin D (n = 55-4122) were included. Taking B vitamins for over 3 months was beneficial for global cognition (standardized mean difference (SMD) -0.18, 95% CI -0.30 to -0.06) and episodic memory (SMD -0.09, 95% CI -0.15 to -0.04). However, antioxidant vitamins (SMD -0.02, 95% CI -0.08 to 0.03) and vitamin D (SMD -0.06, 95% CI -0.36 to 0.23) were not. Antioxidant vitamins were beneficial for global cognition in sensitivity analyses using final measurement data as mean difference estimates (SMD, -0.04, 95% CI -0.08 to -0.01). Taking B vitamins and possibly antioxidant vitamins may be beneficial for the cognitive function of non-demented people.
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Huang CS, Yan YJ, Luo YT, Lin R, Li H. Effects of dance therapy on cognitive and mental health in adults aged 55 years and older with mild cognitive impairment: a systematic review and meta-analysis. BMC Geriatr. 2023 Oct 26;23(1):695. doi: 10.1186/s12877-023-04406-y. PMID: 37880590; PMCID: PMC10601250.
This review reported that dance therapy was effective in improving global cognitive function, memory, executive function, attention, language, and mental health (i.e., depression and neuropsychiatric symptoms). Hence, it may be an effective non-pharmacological complementary treatment for older adults with mild cognitive impairment.
Hoy S, Östh J, Pascoe M, Kandola A, Hallgren M. Effects of yoga-based interventions on cognitive function in healthy older adults: A systematic review of randomized controlled trials. Complement Ther Med. 2021 May;58:102690. doi: 10.1016/j.ctim.2021.102690. Epub 2021 Feb 19. PMID: 33618011.
Yoga-based interventions are associated with improvements in cognition in healthy older adults. Adequately powered RCTs with robust study designs and long-term follow-ups are required. Future studies should explicitly report the intervention characteristics associated with changes in cognitive function.
Li Y, Wang Q, Ren Y, Mao X. Effects of tai chi based on information and communication technology for patients with mild cognitive impairment on cognitive and physical function: a systematic review and meta-analysis. Front Public Health. 2025 Jan 7;12:1495645. doi: 10.3389/fpubh.2024.1495645. PMID: 39839400; PMCID: PMC11748305.
This study confirms the importance of tai chi for cognitive and physical functioning in patients with mild cognitive impairment. Compared with traditional tai chi, communication technology-based tai chi showed greater benefits in promoting rehabilitation.
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